International Review of Ophthalmology

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Current approaches and future prospects of stem cell transplantation for degenerative diseases of retina and optic nerve

LI Xiao-hong, WU Ren-yi.   

  1. Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, Xiamen 361001,  China
  • Received:2017-04-05 Online:2017-06-29 Published:2017-06-29
  • Contact: WU Ren-yi, Email: wubasel@hotmail.com
  • Supported by:

    National Natural Science Foundation of China (81170841, 81570844); Xiamen Scientific and Technologic Fund Program (3502Z20134040, 3502Z20149026)

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Abstract:

Irreversible chronic retinal degenerative diseasesare the main pathology of visual loss, and current clinical management often fails to prevent disease progression.In recent years there has been substantial progress in developing stem cell treatments for these diseases. Stem cell therapy has the potential to both replace lost, and protect damaged, cells by secreting neurotrophic factors. A variety of sources, including embryonic stem cell (ESC), mesenchymal stem cell (MSC), induced pluripotent stem cells (iPSC) and Müller cells show promise as therapeutic approaches for future cell regenerative medicine.(Int Rev Ophthalmol,  2017, 41: 153-158)